ABCB8 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | ABCB8 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rabbit |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µL |
| Concentration | 80 mg/mL |
| Applications | ELISA, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Background: This antibody is designed, produced, and validated as part of a collaboration between Rockland and the National Cancer Institute (NCI) and is suitable for Cancer Research and drug resistance. ABCB8 is designed, produced, and validated as part of a collaboration between Rockland and the National Cancer Institute (NCI). It has been found that ABC transporters are involved in mulitdrug resistance through their ability to contol the presence of drugs in cells. Multidrug resistance is currently being looked at in particular reference to cancer that is resistant to treatment. ABCB8 seems to have particulalrly high resistance rates in renal cancer and cancer of the central nervous system. Another significant aspect of ABCB8 is that it is a mitochondrial transporter. There are very few ABC transporters localized to the mitochondria which implies information about them could be extremely important. ABCB8 may also be localized to other parts of the cell which are yet to be determined. Anti-ABCB8 antibody is ideal for researchers nterested in Cancer Research and drug resistance. Gene Name: ABCB8 Target Information: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined, however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq, Jul 2008]. |
| Immunogen | Immunogen: ABCB8 was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a internal portion of human ABCB8. Immunogen Type: Peptide |
| Other Names | EST328128|M-ABC1|MABC1|ATP-binding cassette sub-family B member 8|mitochondrial|mitochondrial ABC protein|mitochondrial ATP-binding cassette 1|ATP binding cassette subfamily B member 8|ABCB8|ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 8|4833412N02Rik|AA409895|ABC transporter 8|ATP-binding cassette|sub-family B (MDRTAP)|member 8|sub-family B|zgc:113037|mitochondrial-like |
| Gene, Accession # | Gene ID: 7461, 100351012 |
| Catalog # | ABIN5596884 |
| Price | $537 |
| Order / More Info | ABCB8 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
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