Muscarinic Acetylcholine Receptor M2 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | Muscarinic Acetylcholine Receptor M2 |
| Clone | B8E5 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | n/a |
| Applications | Flow Cytometry, Functional Studies, Immunoassay, Immunofluorescence, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The monoclonal antibody B8E5 recognizes human muscarinic acetylcholine receptor M2 (M2 receptor), a G protein-coupled cardiovascular receptor of ~55 kDa. This receptor is an integral membrane protein consisting of seven membrane spanning α-helices linked together by extra- and intracellular loops that form a pharmacophore pocket. Autoantibodies directed against cardiovascular G protein-coupled receptors functionally interfering with the target have been described in several cardiovascular diseases. The M2 receptor is the predominant sybtype of muscarinic receptors present in the heart of mammalian species. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. 2 Monoclonal antibody B8E5 inhibits the β-adrenergic L-type Ca currents through activation of the muscarinic acetylcholine receptor M2. It suggests that the antibody acts not via the classical pathway of decreasing cAMP, but rather by increasing cGMP. Monoclonal antibody B8E5 acts by functional dimerization of the receptor resulting in stabilization of the constitutive active receptor dimers and paradoxically induces a small decrease in carbachol affinity for the M2 receptor. It recognizes the pentapeptide VRTVE (aa 168-172) corresponding to the N-terminal part of the second extracellular loop of the human M2 receptor. M2ACh-R Aliases Peptide VRTVEDGECYIQFFSNAAVTFGTAI(C): Human second extracellular loop residues 168-192 Immunogen Mouse IgG2a Target Information: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]. |
| Immunogen | n/a |
| Other Names | HM2|7TM receptor|acetylcholine receptor|muscarinic 2|muscarinic M2 receptor|muscarinic acetylcholine receptor M2|cholinergic receptor muscarinic 2|CHRM2|Cholinergic Receptor, Muscarinic 2|AChR-M2|Chrm-2|M2|AChR M2|muscarinic acetylcholine receptor 2|cholinergic receptor, muscarinic 2, cardiac|cholinergic receptor|cholinergic receptor, muscarinic 2a|chrm2a|cardiac muscarinic acetylcholine receptor|m2 muscarinic acetylcholine receptor|muscarinic acetylcholine receptor M2-like|Acm2|cardiac|muscarinic receptor m2|GPM2|muscarinic receptor 2 |
| Gene, Accession # | Gene ID: 1129 |
| Catalog # | ABIN2192224 |
| Price | $683 |
| Order / More Info | Muscarinic Acetylcholine Receptor M2 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
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