CD40 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD40 |
| Clone | T8P2G4*A6 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | 200 µg/mL |
| Applications | Flow Cytometry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is specific for the soluble form of CD40.It is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs. Target Information: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. |
| Immunogen | Ovalbumin-conjugated synthetic peptide (RDPVCHPLGA) from the C-terminal of human CD40 |
| Other Names | Bp50|CDW40|TNFRSF5|p50|B cell surface antigen CD40|B cell-associated molecule|B-cell surface antigen CD40|CD40 antigen (TNF receptor superfamily member 5)|CD40 type II isoform|CD40L receptor|nerve growth factor receptor-related B-lymphocyte activation molecule|tumor necrosis factor receptor superfamily member 5|tumor necrosis factor receptor superfamily|member 5|CD40 molecule|CD40|AI326936|GP39|HIGM1|IGM|IMD3|T-BAM|TRAP|T-cell differentiation antigen|CD40 antigen|TNFSF5|human CD40-homologue|TNF receptor superfamily member 5 |
| Gene, Accession # | Gene ID: 958 |
| Catalog # | ABIN6941186 |
| Price | $575 |
| Order / More Info | CD40 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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