CD4 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD4 |
| Clone | OKT4 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b kappa |
| Format | violetFluor™ 500 conjugate |
| Size | 25 tests |
| Concentration | n/a |
| Applications | Flow Cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The OKT4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The OKT4 antibody is widely used as a phenotypic marker for CD4 expression. It is cross-reactive with CD4 in several non-human species, including Chimpanzee, Cynomolgus and Rhesus. This antibody recognizes a different epitope, and thus does not block binding of, the alternative Anti-Human CD4 antibody clone RPA-T4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065) Target Information: This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]. |
| Immunogen | n/a |
| Other Names | CD4mut|CD4 antigen (p55)|CD4 receptor|T-cell surface antigen T4Leu-3|T-cell surface glycoprotein CD4|CD4 molecule|CD4|W325|p55|CD4 antigen|W325 antigen|L3T4|Ly-4|T-cell differentiation antigen L3T4|T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4Leu-3) (T-cell differentiation antigen L3T4)|carcinoembryonic antigen-related cell adhesion molecule 5|LOC100125525|lymphocyte antigen CD4|cell surface glycoprotein CD4|cd1|cd11|cd12|cd19|cd2|cd23|cd5|cd6|cd9|ighv1s1|ighv1s3|ighv1s4|immunoglobulin heavy variable 1 subgroup 1|immunoglobulin heavy variable 1 subgroup 3|immunoglobulin heavy variable 1 subgroup 4|immunoglobulin heavy variable 1-1|ighv1-1 |
| Gene, Accession # | Gene ID: 920 |
| Catalog # | ABIN6961860 |
| Price | $138 |
| Order / More Info | CD4 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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