GAPDHS Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | GAPDHS |
| Clone | 1D4 |
| Host Species | Mouse |
| Reactive Species | porcine |
| Isotype | IgM |
| Format | unconjugated |
| Size | 100 µL |
| Concentration | n/a |
| Applications | Immunofluorescence, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) is a metabolic enzyme responsible for catalyzing one step in the glycolytic pathway, the reversible oxidative phosphorylation of glyceraldehyde 3-phosphate. Because GAPDH is a protein expressed in large amounts and which is required at all times for important house keeping functions, levels of GAPDH mRNA are often measured and used as standards in studies of mRNA expression. Increasingly, scientists are making use of specific antibodies to GAPDH in comparable studies of levels of protein expression. This antibody can be used as a loading control for western blotting experiments, allowing comparison between the level of this protein and others in a cell or tissue. Apart from a role in glycolysis, GAPDH may have other roles such as in the activation of transcription (1). GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer's disease, and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntington's disease (2,3). Associations with actin and tubulin have also been reported. The protein may also have a role in the regulation of apoptosis, and interestingly migrates from the cytoplasm into the nucleus when cells become apoptotic (4). Purification: Unpurified, concentrated culture supernatant. Target Information: This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]. |
| Immunogen | Purified porcine GAPDH |
| Other Names | GAPD2|GAPDH-2|GAPDS|HSD-35|glyceraldehyde-3-phosphate dehydrogenase|testis-specific|spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2|spermatogenic glyceraldehyde-3-phosphate dehydrogenase|glyceraldehyde-3-phosphate dehydrogenase, spermatogenic|GAPDHS|Gapd-s|cb350|fb71f08|fk58c09|g3pdh|gapdh|wu:fb71f08|wu:fk58c09|zgc:76908|glyceraldehyde 3-phosphate dehydrogenase 2|glyceraldehyde 3-phosphate dehydrogenase|spermatogenic|testis-specific-like|glyceraldehyde-3-phosphate dehydrogenase type 2|LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase |
| Gene, Accession # | Gene ID: 100517097 |
| Catalog # | ABIN361377 |
| Price | $553 |
| Order / More Info | GAPDHS Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
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