CD11b Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD11b |
| Clone | M1-70 |
| Host Species | Rat |
| Reactive Species | human, mouse |
| Isotype | IgG2b kappa |
| Format | PE-Cy7 conjugate |
| Size | 25 µg |
| Concentration | n/a |
| Applications | Flow Cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The M1/70 antibody reacts with human and mouse CD11b, also known as integrin alpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha M (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells. The antibody is also reported to be cross-reactive for Rhesus macaque CD11b. Target Information: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]. |
| Immunogen | n/a |
| Other Names | CD11B|CR3A|MAC-1|MAC1A|MO1A|SLEB6|CD11 antigen-like family member B|CR-3 alpha chain|antigen CD11b (p170)|cell surface glycoprotein MAC-1 subunit alpha|integrin alpha-M|leukocyte adhesion receptor MO1|macrophage antigen alpha polypeptide|neutrophil adherence receptor alpha-M subunit|integrin subunit alpha M|ITGAM|Integrin alpha M|CD11bCD18|CR3|F730045J24Rik|Ly-40|MAC1|Mac-1a|CD11B (p170)|Mac-1 alpha|cell surface glycoprotein MAC-1 alpha subunit|complement component receptor 3 alpha-a|complement receptor type 3|macrophage antigen alpha|leukocyte integrin alpha-M chain|integrin, alpha M (complement component 3 receptor 3 subunit)|MAC-1 alpha subunit|LOC100351865|C3bi|complement receptor 3|leukocyte integrin alpha M |
| Gene, Accession # | Gene ID: 3684, 16409 |
| Catalog # | ABIN6961604 |
| Price | $91 |
| Order / More Info | CD11b Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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