CTCFL Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CTCFL |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | 1.28 mg/mL |
| Applications | ELISA, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. BORIS (Brother of the Regulator of Imprinted Sites) also known as CCCTC-binding factor-like protein, is normally only expressed in the testis and expressed in a mutually exclusive manner with CTCF during male germ cell development. However, previous studies have shown that BORIS is abnormally activated in a wide range of human cancers. Expression of BORIS in normally BORIS-negative cells promotes cell growth that may lead to transformation. BORIS maps to the cancer-associated amplification region thought to contain an oncogene or dominant-immortalizing gene. BORIS is a candidate protein for the epigenetic reprogramming factor acting in the male germ line. BORIS is found in both the nucleus and cytoplasm.Target Information: CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]. |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding aa 9-26 of human BORIS protein. |
| Other Names | BORIS|CT27|CTCF-T|HMGB1L1|dJ579F20.2|BORIS-like protein|CTCF paralog|CTCF-like protein|HMG-1L1|brother of the regulator of imprinted sites|cancer estis antigen 27|putative high mobility group protein 1-like 1|putative high mobility group protein B1-like 1|transcriptional repressor CTCFL|zinc finger protein CTCF-T|CCCTC-binding factor like|CTCFL|CCCTC-Binding Factor (Zinc Finger Protein)-Like|CCCTC-binding factor-like protein|OTTMUSG00000016680|likely orthologue of H. sapiens CCCTC-binding factor-like protein (CTCFL)|brother of regulator of imprinted sites|transcriptional repressor CTCFL-like |
| Gene, Accession # | Gene ID: 140690 |
| Catalog # | ABIN129668 |
| Price | $537 |
| Order / More Info | CTCFL Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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