TAF1 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | TAF1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | 1.15 mg/mL |
| Applications | ELISA, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Transcription Initiation Factor TFIID Subunit 1 (TAF1) is the largest component and core scaffold of the TFIID basal transcription factor complex, which also includes TATA-binding protein (TBP) and a variety of TBP-associated factors. TFIID nucleates the formation of transcription pre-initiation complexes and plays a key role in the regulation of gene expression by RNA polymerase II. TAF1 possesses DNA-binding activity and also contains novel N- and C-terminal Ser/Thr kinase domains which can auto-phosphorylate or trans-phosphorylate other transcription factors. For example, TAF1 interacts with the C-terminus of TP53 and phosphorylates the T55 residue, leading to MDM2-mediated degradation of TP53. TAF1 also catalyzes Ser phosphorylation of general transcription factor IIA (GTF2A1) and IIF (GTF2F1). The retinoblastoma tumor suppressor protein, RB1, interacts with the N-terminal domain of TAF1 and inhibits its intrinsic kinase activity. TAF1 is essential for progression through the G1 phase of the cell cycle and has been reported to be indispensable for expression of 18% of mammalian genes.Target Information: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.[provided by RefSeq, Aug 2009]. |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the of human TAF1. |
| Other Names | BA2R|CCG1|CCGS|DYT3|DYT3TAF1|KAT4|N-TAF1|NSCL2|OF|P250|TAF2A|TAFII250|XDP|TAF(II)250|TAFII-250|TBP-associated factor 250 kDa|cell cycle gene 1 protein|cell cycle|G1 phase defect|complementation of cell cycle block|G1-to-S|transcription factor TFIID p250 polypeptide|transcription initiation factor TFIID 250 kDa subunit|transcription initiation factor TFIID subunit 1|TATA-box binding protein associated factor 1|TAF1|TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa|transcription initiation factor TFIID|subunit TAF1|transcription initiation factor TFIID, subunit TAF1|HAF1501|HAF1502|RGD1562050|TAF1 RNA polymerase II|TATA box binding protein (TBP)-associated factor|250kDa|LOC5567420|CpipJ_CPIJ003658|TAF11.1|BG:DS00004.13|CG17603|DmelCG17603|EfW1|SR3-5|TAF|TAF200|TAF230|TAF250|TAF250230|TAFII|TAFII230|TAFII250230|TFIID|TFIID TAF250|Taf1p|cel|cell|d230|dTAF230|dTAF250|dTAFII250|dTAFII230|dmTAF1|dmTAFII230|l(3)84Ab|p230|CG17603-PA|CG17603-PB|CG17603-PC|CG17603-PD|CG17603-PE|TATA-associated factor 250|TBP-associated factor|TBP-associated factor 250|TBP-associated factor 250kD|TFIID 230 kda subunit|Taf1-PA|Taf1-PB|Taf1-PC|Taf1-PD|Taf1-PE|cell lethal|suppressor of Ras85D 3-5|TBP-associated factor 1|TBP-associated factor 1-like|transcription initiation factor TFIID subunit 1-like|LOC100457071|AU015687|B430306D02Rik|Ccg-1|neuron specific isoform |
| Gene, Accession # | Gene ID: 6872 |
| Catalog # | ABIN233826 |
| Price | $537 |
| Order / More Info | TAF1 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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