Description | ATG8E,Autophagy-related protein LC3 A,Autophagy-related ubiquitin-like modifier LC3 A,LC3,LC3A,MAP1 light chain 3 like protein 1,MAP1 light chain 3-like protein 1,MAP1A/1B light chain 3 A,MAP1A/MAP1B LC3 A,MAP1A/MAP1B light chain 3 A,MAP1ALC3,MAP1BLC3,Map1lc3a,Microtubule associated proteins 1A/1B light chain 3,Microtubule-associated protein 1 light chain 3 alpha,Microtubule-associated proteins 1A and 1B,light chain 3,Microtubule-associated proteins 1A/1B light chain 3A,MLP3A,LC3,also known as microtubule-associated protein 1 light chain 3 (MAP1LC3),is a mammalian homolog of the yeast Atg8p (autophagy-related 8 protein) that is involved in autophagy process. Three isoforms of LC3 exist as LC3A,LC3B,and LC3C. LC3 is first synthesized as pro-LC3,and undergoes C-terminal cleavage to yield a cytosolic precursor known as LC3-I. During autophagy LC3-I is subsequently conjugated to PE lipid as lipidated form: LC3-II. The lipidated form migrates faster on SDS-PAGE gel. The increased the level of LC3-II has been widely used as autophagy marker. This antibody recognizes both LC3-I and LC3-II. Target Information: MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]. |