TBP Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | TBP |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 120 µL |
| Concentration | 0.8 mg/mL |
| Applications | ELISA, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The TATA binding protein (TBP) is a transcription factor that binds specifically to a DNA sequence TATA box. This DNA sequence is found about 25-30 base pairs upstream of the transcription start site in some eukaryotic gene promoters. TBP,along with a variety of TBP-associated factors,make up the TFIID,a general transcription factor that in turn makes up part of the RNA polymerase II preinitiation complex. As one of the few proteins in the preinitation complex that binds DNA in a sequence-specific manner,it helps position RNA polymerase II over the transcription start site of the gene. However,it is estimated that only 10-20% of human promoters have TATA boxes. Therefore,TBP is probably not the only protein involved in positioning RNA polymerase II. This antibody detects human TBP (~40 kDa) and mouse/rat Tbp (~35 kDa). Target Information: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]. |
| Immunogen | Full length fusion protein |
| Other Names | GTF2D|GTF2D1|HDL4|SCA17|TFIID|TATA sequence-binding protein|TATA-box binding protein N-terminal domain|TATA-box factor|TATA-box-binding protein|transcription initiation factor TFIID TBP subunit|TATA-box binding protein|TBP|TATA Box Binding Protein|TATA-binding factor|TATA-binding protein|TFIID core protein|fd20h06|si:zc101n13.2|wu:fd20h06|zgc:66213|zTBP|zfTBF|TBP1|TA-TA binding protein 1|TATA binding protein|CG9874|DmelCG9874|RBP|TBP38|TFIIDtau|dTBP|dTFIID|42kDa polypeptide|CG9874-PA|TATA box-binding protein|Tbp-PA|xtbp|transcription factor|TATA-box binding protein L homeolog|tbp.L|tbp-a|tbp-b|TATA-box binding protein S homeolog|tbp.S |
| Gene, Accession # | Gene ID: 6908 |
| Catalog # | ABIN7245697 |
| Price | $319 |
| Order / More Info | TBP Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
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