HLA-DRA Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | HLA-DRA |
| Clone | 169-1B5-2 |
| Host Species | Mouse |
| Reactive Species | cat, cow, human |
| Isotype | IgG2b kappa |
| Format | unconjugated |
| Size | 20 µg |
| Concentration | 200 µg/mL |
| Applications | Flow Cytometry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody detects a monomorphic general framework determinant of HLA-DR Class II antigen.It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4Molecules, HLA-DR is critical for efficient peptide presentation to CD4 T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Target Information: HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]. |
| Immunogen | Human peripheral blood leukocytes |
| Other Names | HLA-DRA1|MLRW|HLA class II histocompatibility antigen|DR alpha chain|MHC cell surface glycoprotein|MHC class II antigen DRA|histocompatibility antigen HLA-DR alpha|major histocompatibility complex, class II, DR alpha|HLA-DRA|HLA Class II DR alpha|major histocompatibility complex|class II|DR alpha|major histocompatibility complex, class II, DR alpha L homeolog|hla-dra.L|DR-alpha|Mamu-DRA1|MHC class II DRA|MHC class II antigen|MAMU-DRA|BoLA-DR-alpha|BOLA-DRA|RLA-DR-ALPHA|h2-ea |
| Gene, Accession # | Gene ID: 3122, 506214 |
| Catalog # | ABIN6935841 |
| Price | $274 |
| Order / More Info | HLA-DRA Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
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