HSP90 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | HSP90 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, Immunohistochemistry, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Hsp90 is a member of the heat shock protein 90 family, the members of which are highly conserved between isoforms and species. Hsp90 functions as a molecular chaperone and has ATPase activity. Hsp90 is a cytoplasmic protein that forms a homodimer in vivo and interacts with TOM34, AHSA1, HDAC6 and SMYD3. Several signal transduction pathways depend on Hsp90 function, including pathways involving erbB2, hypoxia sensitivity (Hif1 alpha), and steroid hormone receptors (for example, androgen, progesterone, glucocorticoid, and aryl-hydrocarbon). Recent reports show that Hsp90 from tumor cells has increased sensitivity to small molecule inhibitors (for example, 17AAG). The mechanism of the differential sensitivity of Hsp90 from normal versus tumor cells is unknown, although mutation has been ruled out. One possible mechanism may be differences in post-translational modification of tumor Hsp90. K294 was found to be acetylated in purified Hsp90 from SkBr3 cells, a breast cancer cell line.Target Information: This gene encodes a member of the heat shock protein 90 family, these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]. |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids surrounding K294 of human Hsp90. |
| Other Names | EL52|HSP86|HSP89A|HSP90A|HSP90N|HSPC1|HSPCA|HSPCAL1|HSPCAL4|HSPN|Hsp89|Hsp90|LAP2|HSP 86|epididymis luminal secretory protein 52|heat shock 86 kDa|heat shock 90kD protein 1|alpha|alpha-like 4|heat shock 90kD protein|heat shock 90kDa protein 1|heat shock protein HSP 90-alpha|renal carcinoma antigen NY-REN-38|heat shock protein 90 alpha family class A member 1|HSP90AA1|Heat Shock Protein 90|heat shock protein Hsp90|git10|swo1|Hsp90 chaperone|daf-21|chaperone protein HtpG|htpG|SCBAC25F8.08|SCO7516|molecular chaperone HtpG|MAP_RS10510|TP04_0646|TP01_0934|APH_RS03525|GbCGDNIH1_0315|MAV_2118|HSP90C|23.m06066|BBOV_IV008400|17.m07646|BBOV_III007380|ACICU_00312|ECL_01244|YE105_C1172|HSP90-1|uncharacterized LOC100384473|pco153543(105)|143198_at|83|83K HSP|DMHSP82|E(sev)3A|E(sina)2|HSP82|HSP83|ORF1|Su(Raf)3A|anon-EST:Liang-2.53|anon-WO0068693|anon-WO0140519.209|clone 2.53|en(lz)3C4C|hsp84|l(3)j5C2|ms(3)08445|stc|DmelCG1242|CG1242|heat shock protein 83|CG1242-PA|Hsp83-PA|enhancer of sevenless 3A|scratch|enhancer of seven in absentia 2|heat shock protein 1|heat shock protein 86|heat shock protein 90, alpha (cytosolic), class A member 1|86kDa|89kDa|AL024080|AL024147|Hsp86-1|hsp4|TSTA|heat shock protein 90kDa alpha (cytosolic)|class A member 1|heat shock protein|1|86 kDa 1|89 kDa|tumor-specific transplantation 86 kDa antigen|90-kDa heat shock protein|Heat shock protein HSP 90-beta-like protein|heat shock protein HSP 90-beta|heat shock protein 90 alpha family class B member 1|HSP90AB1|hsp90 alpha|hsp90alpha.1|heat shock protein 90kDa alpha family class A member 1 L homeolog|hsp90aa1.1.L|Hsp90alpha|LOC108698781|heat shock protein-90 |
| Gene, Accession # | Gene ID: 3320 |
| Catalog # | ABIN233817 |
| Price | $537 |
| Order / More Info | HSP90 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
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