NOVA1 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | NOVA1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | Alexa Fluor 750 conjugate |
| Size | 100 µL |
| Concentration | 1 µg/µL |
| Applications | Immunofluorescence (Cultured Cells), Immunofluorescence (Paraffin-embedded Sections) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5). Subcellular location: Nucleus Target Information: This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthetic peptide derived from human Nova1 |
| Other Names | Nova-1|RNA-binding protein Nova-1|onconeural ventral antigen 1|paraneoplastic Ri antigen|ventral neuron-specific protein 1|NOVA alternative splicing regulator 1|NOVA1|Neuro-Oncological Ventral Antigen 1|neuro-oncological ventral antigen 1 L homeolog|nova1.L|si:ch211-222c22.9|9430099M15Rik|G630039L02|LOC790874|lipid A export ATP-bindingpermease protein|lipid A export ATP-binding/permease protein |
| Gene, Accession # | Gene ID: 4857, 298992, 664883 |
| Catalog # | ABIN5007787 |
| Price | $470 |
| Order / More Info | NOVA1 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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