CD161 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD161 |
| Clone | HP-3G10 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | violetFluor™ 450 conjugate |
| Size | 25 tests |
| Concentration | n/a |
| Applications | Flow Cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The HP-3G10 antibody is specific for human CD161, also known as NKR-P1A, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer which is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4 T cells, and CD8 T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL- 17A cells are contained within the CD161 fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells.The HP-3G10 antibody may be used for flow cytometric analysis of CD161 on NK and NKT cells, as well as on various T cell subsets. The antibody is also reported to be cross-reactive with Baboon, Chimpanzee and Rhesus CD161. Target Information: Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]. |
| Immunogen | n/a |
| Other Names | CD161|CLEC5B|NKR|NKR-P1|NKR-P1A|NKRP1A|hNKR-P1A|C-type lectin domain family 5 member B|killer cell lectin-like receptor subfamily B member 1|natural killer cell surface protein P1A|killer cell lectin like receptor B1|KLRB1|Killer Cell Lectin-Like Receptor Subfamily B, Member 1|natural killer cell receptor protein 1 variant 1|natural killer cell receptor protein 1 variant 2|natural killer cell receptor protein 1 variant 3|killer cell lectin-like receptor subfamily B|member 1|4930431A04Rik|Gm4696|Klrb1g|Klrb6|Ly-55|Ly55|NKR-P1G|Nkrp-1e|Nkrp1g|immunoreceptor NKR-P1G|killer cell lectin-like receptor subfamily A member 1 complex|killer cell lectin-like receptor subfamily B member 1 complex|killer cell lectin-like receptor subfamily B member 1G|lectin-like transmembrane protein Nkrp1g|lymphocyte antigen 55|natural killer cell surface protein NKR-P1G|natural killer lectin-like receptor 1E|natural killer lectin-like receptor protein 1 e|Klrb1d|Klrb1f|Nkr-p1e|immunoreceptor NKR-P1E|killer cell lectin-like receptor subfamily B member 1F |
| Gene, Accession # | Gene ID: 3820 |
| Catalog # | ABIN6961815 |
| Price | $137 |
| Order / More Info | CD161 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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52072 Aachen GERMANY
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