CD8 alpha Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD8 alpha |
| Clone | OX-8 |
| Host Species | Mouse |
| Reactive Species | rat |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 100 µg |
| Concentration | 0.1 mg/ml |
| Applications | Flow Cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | anti-rat CD8a monoclonal antibody recognizes a determinant on the majority of thymocytes (90-95%), a subset of peripheral T cells, the majority of NK cells, and the granular intraepithelial leukocytes in the small intestine. (1,2,3,4.) The antigen recognized is a complex of surface glycoproteins of Mr 34,000, 39,000 and 76,000 Da and is the rat homologue of the human CD8 and the mouse Ly-2,3 antigen. (5,8) ABIN133186labels all peripheral T cells that are unlabelled by the ABIN133186(W3/25) monoclonal antibody. It labels a T-cell subset which mediates the suppression of antibody formation (1) and the cytotoxic cell precursor. (2) ABIN133186and ABIN133186can be used together to fractionate T cells by sorting in FACS or by rosette depletion (1,2) or can be used together to study subsets of T cells in the rat which mediate lethal graft vs. host disease. (7) This antibody is one of the 3 monoclonal antibodies which labels T lymphocyte populations in the rat, these being ABIN133186(W3/13) which labels all T cells, as well as ABIN133186(W3/25) and CL004F? (MRC 0X-8) which label non-overlapping T cell populations. These monoclonal antibodies used in concert are being employed extensively to investigate cellular aspects of the immune response in rats and prove to be useful as markers for functionally distinct subpopulations of lymphocytes. This clone is reported to work with frozen and paraffin sections (9). Target Information: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]. |
| Immunogen | High molecular weight rat thymocyte glycoproteins . Fusion Partner: P3-NSI-1-Ag4 (NSI/1) . Donor: BALB/c spleen |
| Other Names | CD8|Leu2|MAL|p32|CD8 antigen|alpha polypeptide (p32)|Leu2 T-lymphocyte antigen|OKT8 T-cell antigen|T cell co-receptor|T-cell antigen Leu2|T-cell surface glycoprotein CD8 alpha chain|T-lymphocyte differentiation antigen T8Leu-2|T8 T-cell antigen|CD8a molecule|CD8A|CD8 alpha|BB154331|Ly-2|Ly-35|Ly-B|Lyt-2|Lyt-2.1 lymphocyte differentiation antigen (AA at 100)|T-cell surface glycoprotein Lyt-2|CD8 antigen, alpha chain|CD8 antigen 32 kDa chain|CD8 antigen alpha-chain|alpha chain|alpha-chain|OX-8 membrane antigen|zgc:136643|alpha polypeptide|uncharacterized LOC100125537|LOC100125537|LOC100136450|T-cell surface glycoprotein CD8 alpha chain-like|CD8 alpha chain|CD8 antigen alpha polypeptide|T-cell surface molecule|RHACD8-4|CD8 alpha molecule|LOC100126556 |
| Gene, Accession # | Gene ID: 24930 |
| Catalog # | ABIN133186 |
| Price | $280 |
| Order / More Info | CD8 alpha Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
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