HMGB1 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | HMGB1 |
| Clone | Giby-1-4 |
| Host Species | Human |
| Reactive Species | human, mouse, rat |
| Isotype | IgG2 |
| Format | biotin conjugate |
| Size | 100 µg |
| Concentration | lot specific |
| Applications | ELISA, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localized innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also a causative agent of various diseases as it causes localized inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis. Anti-HMGB1, mAb (recombinant) (Giby-1-4) (Biotin) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein. Target Information: a transcriptional regulator that may play a central role in the stabilization and/or assembly of several multifunctional complexes through protein-protein interactions [RGD, Feb 2006]. |
| Immunogen | Human recombinant HMGB1. |
| Other Names | HMG1|HMG3|SBP-1|Amphoterin|HMG-1|Sulfoglucuronyl carbohydrate binding protein|high mobility group protein 1|high mobility group protein B1|high-mobility group (nonhistone chromosomal) protein 1|high-mobility group box 1|high mobility group box 1|HMGB1|DEF|p30|ik:tdsubc_1a5|wu:fb23c02|xx:tdsubc_1a5|zgc:56110|zgc:77104|tdsubc_1a5|high mobility group box 1a|hmgb1a|high mobility group box 1 L homeolog|hmgb1.L|high mobility group 1 protein|high mobility group protein HMG1|non-histone protein HMG1|high mobility group protein B1-like protein|high mobility group protein B1-like|Ac2-008|heparin-binding protein p30|high mobility group 1|LOC100359149 |
| Gene, Accession # | Gene ID: 3146, 15289, 25459 |
| Catalog # | ABIN1169271 |
| Price | $515 |
| Order / More Info | HMGB1 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
P: +49 (0)241 95 163 153
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