SQSTM1 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | SQSTM1 |
| Clone | R08-4H8 |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | IgG |
| Format | unconjugated |
| Size | 50 µL |
| Concentration | 300 µg/mL |
| Applications | Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | As a autophagy-specific substrate,p62 is degraded during the autophagic process,which makes intracellular level of p62 as a marker for autophagy flux. p62 is at the cross-roads of several signaling pathways including Ras/ Raf/ MAPK and NFκB and plays important role in cancer. p62 is a component of inclusion bodies/ protein aggregates found in human diseases,including Huntington's disease,Alzheimer's disease,Parkinson's disease in the brain,and nephropathic cystinosis in kidney (22074114,22860231,22714671). The molecular weight of p62 is predicted as 48/ 38 kDa,while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues. Target Information: This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]. |
| Immunogen | n/a |
| Other Names | A170|OSIL|PDB3|ZIP3|p60|p62|p62B|EBI3-associated protein of 60 kDa|EBI3-associated protein p60|EBIAP|oxidative stress induced like|phosphotyrosine independent ligand for the Lck SH2 domain p62|phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa|sequestosome-1|ubiquitin-binding protein p62|sequestosome 1|SQSTM1|OSF-6|Osi|STAP|STONE14|oxidative stress induced|sequestosome 1 L homeolog|sqstm1.L|sb:cb621|zgc:85784|sequestosome-1-like|MGC79491|sqstm1 protein|ZIP|PKC-zeta-interacting protein|protein kinase C-zeta-interacting protein|LOW QUALITY PROTEIN: sequestosome-1 |
| Gene, Accession # | Gene ID: 8878 |
| Catalog # | ABIN7384397 |
| Price | $242 |
| Order / More Info | SQSTM1 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
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