CD45 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD45 |
| Clone | F10-89-4 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a kappa |
| Format | PerCP conjugate |
| Size | 200 tests |
| Concentration | 50 µg/mL |
| Applications | Flow Cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The clone F10-89-4, a mouse monoclonal antibody, recognizes a hematopoietic cell surface antigen known as CD45 which is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and basophils in peripheral blood. CD45 has a role in signal transduction, modifying signals from other surface molecules. The CD45 antibody has been reported to react weakly with mature circulating erythrocytes and platelets. The antibody recognizes the human leukocyte common antigen which is found on cells from spleen, lymph nodes, 83% bone marrow cells, and granulocytes. The antigen recognized by F10-89-4 is a glycoprotein with a molecular weight of 190 kDa to 215 kDa. Target Information: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]. |
| Immunogen | Human T lymphocytes |
| Other Names | B220|CD45|CD45R|GP180|L-CA|LCA|LY5|T200|CD45 antigen|T200 glycoprotein|T200 leukocyte common antigen|protein tyrosine phosphatase|receptor type|c polypeptide|receptor-type tyrosine-protein phosphatase C|protein tyrosine phosphatase, receptor type C|PTPRC|Protein tyrosine Phosphatase, Receptor Type, C|RT7|receptor-type|leucocyte common antigen|leukocyte common antigen A|leukocyte common antigen B|leukocyte common antigen|C|si:dkeyp-47c5.1|LOC100074271|receptor-type tyrosine-protein phosphatase C-like|Ly-5|Lyt-4|loc|lymphocyte antigen 5|lymphocyte common antigen|membrane tyrosine phosphatase|LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C-like|LOC109046999 |
| Gene, Accession # | Gene ID: 5788 |
| Catalog # | ABIN2704289 |
| Price | $611 |
| Order / More Info | CD45 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
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