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Antigenic Specificity | TNFRSF1A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 100 µg |
Concentration | n/a |
Applications | Immunoassay, Immunoprecipitation, Western Blotting |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody reacts with the extra-cellular part of the TNF-R I and with the soluble receptor. TNF-R I is present on most cell types and is considered to play a prominent role in cell stimulation by TNF-alpha. Induction of cytotoxicity and other functions are mediated largely via TNF-R I. Target Information: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]. |
Immunogen | n/a |
Other Names | CD120a|FPF|MS5|TBP1|TNF-R|TNF-R-I|TNF-R55|TNFAR|TNFR1|TNFR1-d2|TNFR55|TNFR60|p55|p55-R|p60|TNF-R1|TNF-RI|TNFR-I|tumor necrosis factor binding protein 1|tumor necrosis factor receptor 1A isoform beta|tumor necrosis factor receptor superfamily member 1A|tumor necrosis factor receptor type 1|tumor necrosis factor-alpha receptor|TNF receptor superfamily member 1A|TNFRSF1A|Tumor Necrosis Factor Receptor Superfamily, Member 1A|TNF-alphaR1|TNFRI|TNFRp55|TNFalpha-R1|Tnfr-2|TNF receptor alpha chain|TNF-alpha-R1|tumor necrosis factor receptor 1|tumor necrosis factor receptor type I|xtnfr1|TNF receptor superfamily member 1A S homeolog|tnfrsf1a.S|p55 TNF receptor|tumor necrosis factor receptor p60|wu:fj65b10|zgc:85914|TNF Receptor 1 (TR1)|TNFR I|tumor necrosis factor type I|tumor necrosis factor receptor superfamily|member 1A|tumor necrosis factor receptor superfamily member 1A-like|TNFA|cTNF|TNF-a|TNF-alpha|cachectin|tumor necrosis factor (TNF superfamily|member 2)|tumor necrosis factor alpha|tumor necrosis factor ligand superfamily member 2|tumour necrosis factor|tumor necrosis factor|TNF |
Gene, Accession # | Gene ID: 7132 |
Catalog # | ABIN2192176 |
Price | $756 |
Order / More Info | TNFRSF1A Antibody from ANTIBODIES-ONLINE GmbH |
Product Specific References | n/a |