CD11c Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD11c |
| Clone | 3-9 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | APC-Cy7 conjugate |
| Size | 100 tests |
| Concentration | n/a |
| Applications | Flow Cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The 3.9 antibody reacts with human CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The 3.9 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on activated neutrophils, granulocytes, some types of activated T cells and intestinal intraepithelial lymphocytes (IEL). The antibody is reported to be cross-reactive with Baboon, Chimpanzee, Cynomolgus and Rhesus CD11c. Target Information: This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. [provided by RefSeq, Jul 2008]. |
| Immunogen | n/a |
| Other Names | CD11C|SLEB6|CD11 antigen-like family member C|integrin alpha-X|integrin|alpha X (antigen CD11C (p150)|alpha polypeptide)|leu M5|alpha subunit|leukocyte adhesion glycoprotein p150|95 alpha chain|leukocyte adhesion receptor p150|95|leukocyte surface antigen p150|myeloid membrane antigen|p150 95 integrin alpha chain|integrin subunit alpha X|ITGAX|Integrin, alpha X (Complement Component 3 Receptor 4 Subunit)|RGD1561123|AI449405|Cr4|N418|CD11C (p150) alpha polypeptide|complement receptor 4|integrin aX|integrin alpha X |
| Gene, Accession # | Gene ID: 3687 |
| Catalog # | ABIN7278057 |
| Price | $399 |
| Order / More Info | CD11c Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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