Mre11 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | Mre11 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | 1.05 mg/mL |
| Applications | ELISA, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Mre11 is a component of the MRN complex (Mre11/Rad50/Nbs1), which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex mayTarget Information: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog, this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corres-ponding to amino acids 68-706 of mouse Mre11 protein. Immunogentype:Recombinant |
| Other Names | ATLD|HNGS1|MRE11|MRE11B|AT-like disease|DNA recombination and repair protein|MRE11 homolog 1|MRE11 homolog A|double-strand break repair protein MRE11A|endoexonuclease Mre11|meiotic recombination 11 homolog 1|meiotic recombination 11 homolog A|MRE11 homolog, double strand break repair nuclease|MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae)|MRE11A|MRE11 homolog A, double strand break repair nuclease|wu:faa63d12|zgc:64018|mmMRE11A|MRE11A homolog A, double strand break repair nuclease|meiotic recombination 11-like protein|double strand break repair nuclease|MRE11 meiotic recombination 11 homolog A|double-strand break repair protein MRE11|mre11-a|mre11a.L|double strand break repair nuclease L homeolog|MRE11 homolog|double strand break repair nuclease A|putative nuclease Mre11|MRE11 homolog, double strand break repair nuclease L homeolog|mre11.L |
| Gene, Accession # | Gene ID: 17535 |
| Catalog # | ABIN129662 |
| Price | $537 |
| Order / More Info | Mre11 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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