Fibrillarin Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | Fibrillarin |
| Clone | 38F3 |
| Host Species | Mouse |
| Reactive Species | Saccharomyces cerevisiae |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 100 µL |
| Concentration | n/a |
| Applications | Immunofluorescence, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Nop1p was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae. The Nop1p protein is 327 amino acids in size (34.5kDa), is essential for yeast viability, and is localized in the nucleoli (1). The systematic name for S. cerevisiae Nop1 is YDL014W, and it is now known to be part of the small subunit processome complex, involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of a protein found in all eukaryotes and archea generally called fibrillarin (2). Fibrillarin/Nop1p is extraordinarily conserved, so that the yeast and human proteins are 67% identical, and the human protein can functionally replace the yeast protein. Patients with the autoimmune disease scleroderma often have strong circulating autoantibodies to a ~34kDa protein which was subsequently found to be fibrillarin. Recent studies show that knock-out of the fibrillarin gene in mice results in embryonic lethality, although mice with only one functional fibrillarin/Nop1p gene were viable (3). This antibody is becoming widely used as a convenient marker for nucleoli in a wide variety of species (e.g. 4-6). Target Information: This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]. |
| Immunogen | Yeast nuclear preparations |
| Other Names | FIB|FLRN|RNU3IP1|34 kDa nucleolar scleroderma antigen|34-kD nucleolar scleroderma antigen|RNA|U3 small nucleolar interacting protein 1|rRNA 2'-O-methyltransferase fibrillarin|fibrillarin|FBL|wu:fb37g12|zgc:56145|zgc:77130|fb37g12|nucleolar protein 1|AL022665|CG9888|DmelCG9888|Fibri|GCR-6|GCR6|Pen59C5|CG9888-PA|Fib-PA|MGC76139|fib1|putative fibrillarin|LMJF_19_0100|histone-glutamine methyltransferase|fibrillarin S homeolog|fbl.S |
| Gene, Accession # | Gene ID: 2091, 14113 |
| Catalog # | ABIN361375 |
| Price | $481 |
| Order / More Info | Fibrillarin Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
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