Desmoplakin Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | Desmoplakin |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µL |
| Concentration | n/a |
| Applications | Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The desmoplakin (DP) is the most abundant desmosomal proteins and is located at the cytoplasmic portion of the desmosomes which are specialized cell-cell adhesion structures abundant in tissues such as muscle and epidermis that are subjected to mechanical stress. Desmoplakin 1 and 2 (DP 1 and 2) are two splice variants sharing common C-terminal and N-terminal globular head and tail domains, but differ in the length of the rod domain that links them. This antibody detects both DP1 (280-330 kDa) and DP2 (240-260 kDa). Target Information: Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]. |
| Immunogen | Recombinant protein corresponding to Mouse Desmoplakin |
| Other Names | DP|DPI|DPII|250210 kDa paraneoplastic pemphigus antigen|desmoplakin I|desmoplakin II|desmoplakin|DSP|PhopGV104|ORF-59 desmoplakin|desmop|putative desmoplakin|ORF113|2300002E22Rik|5730453H04Rik|AA407887|AA407888|AW109828|desmoplakin III|desmosomal cytoskeletal connector molecule|im:6911953|sb:cb570|wu:fc17a08|wu:fk73d01|fk73d01|desmoplakin a|dspa|ORF112 DESMOPLAKIN|orf102|ClgVgp102|orf91; similar to Cydia pomonella granulovirus orf112|COGV_gp091|ORF62|APNV_p087|ORF-66|CBNV_gp066|ORF57|EONV_gp057|OLNV_gp066|agip105|AgipMNPV_gp105|HaMNV_gp106|EupsNPV_gp065|similar to XcORF133; similar to HaGV desmoplakin|PsunGV_gp139|desmoplakin-related protein|desmoplakin L homeolog|dsp.L|ORF96|ClanGV_gp096 |
| Gene, Accession # | Gene ID: 1832, 109620, 306871 |
| Catalog # | ABIN7073719 |
| Price | $286 |
| Order / More Info | Desmoplakin Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
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