CD3 epsilon Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD3 epsilon |
| Clone | 145-2C11 |
| Host Species | Armenian Hamster |
| Reactive Species | mouse |
| Isotype | IgG |
| Format | PerCP conjugate |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This fact identifies e-T3 as a cell surface protein involved in the transduction of activation signals. All peripheral T cells express this determinant, however, B cells and bone marrow cells have proven to be negative. Although the expression of this particular epitope on peripheral T cells is uniformly high, staining of thymocytes reveals distinct subpopulations of cells differing in the level of expression of this marker. This antibody will prove useful in studying the role of various components of the TCR complex in T cell activation and development, and will allow for the development of an animal model in which to investigate the immunoregulatory effects of in vivo administration of anti-CD3 antibodies, an area of obvious clinical importance. Anti-CD3e is ideal for flow cytometry applications, particularly as a specific marker for tracking mouse T cells. addition, this monoclonal antibody, clone 145-2C11 was specifically designed to trigger T cell activation. Target Information: The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]. |
| Immunogen | H-2Kb-specific mouse cytotoxic T lymphocyte clone BM10-37 |
| Other Names | T3E|TCRE|CD3-epsilon|CD3e antigen|epsilon polypeptide (TiT3 complex)|T-cell antigen receptor complex|epsilon subunit of T3|T-cell surface antigen T3Leu-4 epsilon chain|T-cell surface glycoprotein CD3 epsilon chain|CD3e molecule|CD3E|CD3 epsilon|epsilon polypeptide|TiT3 complex|antigen CD3E|CD3|CD3 epsilon subunit|CD3 Epsilon chain|CD3 antigen epsilon|epsilon (CD3-TCR complex)|AI504783|CD3epsilon|CD3 antigen, epsilon polypeptide|CD3 antigen|CD3 molecule|CD3 epsilon antigen |
| Gene, Accession # | Gene ID: 12501 |
| Catalog # | ABIN1112448 |
| Price | $600 |
| Order / More Info | CD3 epsilon Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
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