PDCD4 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | PDCD4 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 25 µL |
| Concentration | 0.95 mg/mL |
| Applications | ELISA, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphorylation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun.Target Information: This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]. |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids surrounding Ser457 in the human Pdcd4 protein. |
| Other Names | H731|neoplastic transformation inhibitor protein|nuclear antigen H731|programmed cell death protein 4|protein 19715a|programmed cell death 4|PDCD4|D19Ucla1|Ma3|Tis|protein MA-3|topoisomerase-inhibitor suppressed protein|Dug|death up-regulated gene protein|death-upregulated|cb45|sb:cb45|wu:fc84b08|programmed cell death 4b|pdcd4b|programmed cell death 4 L homeolog|pdcd4.L|protein I116|programmed cell death 4 (neoplastic transformation inhibitor)|MGC69337|programmed cell death protein 4-like |
| Gene, Accession # | Gene ID: 27250 |
| Catalog # | ABIN1607873 |
| Price | $181 |
| Order / More Info | PDCD4 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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52072 Aachen GERMANY
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