CD45 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD45 |
| Clone | 2D1 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | iFluor™488 conjugate |
| Size | 100 tests |
| Concentration | n/a |
| Applications | Flow Cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The clone 2D1, a mouse monoclonal antibody, recognizes a hematopoietic cell surface glycoprotein antigen with a molecular weight of 180-220 kDa known as CD45. It is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and basophils in peripheral blood. CD45 has a role in signal transduction, modifying signals from other surface molecules. 2D1 has been reported to react weakly with mature circulating erythrocytes and platelets. The antibody also recognizes the human leukocyte common antigen found on cells from spleen, lymph nodes, bone marrow cells and granulocytes. Target Information: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]. |
| Immunogen | Human PBMC |
| Other Names | B220|CD45|CD45R|GP180|L-CA|LCA|LY5|T200|CD45 antigen|T200 glycoprotein|T200 leukocyte common antigen|protein tyrosine phosphatase|receptor type|c polypeptide|receptor-type tyrosine-protein phosphatase C|protein tyrosine phosphatase, receptor type C|PTPRC|Protein tyrosine Phosphatase, Receptor Type, C|RT7|receptor-type|leucocyte common antigen|leukocyte common antigen A|leukocyte common antigen B|leukocyte common antigen|C|si:dkeyp-47c5.1|LOC100074271|receptor-type tyrosine-protein phosphatase C-like|Ly-5|Lyt-4|loc|lymphocyte antigen 5|lymphocyte common antigen|membrane tyrosine phosphatase|LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C-like|LOC109046999 |
| Gene, Accession # | Gene ID: 5788 |
| Catalog # | ABIN7077251 |
| Price | $350 |
| Order / More Info | CD45 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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