IRGM Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | IRGM |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | 1 mg/mL |
| Applications | ELISA, Immunofluorescence, Immunohistochemistry (Paraffin-embedded Sections), Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | IRGM Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa that also includes IRGM2 and IRGM3, this antibody may also recognize these proteins. Target Information: This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010]. |
| Immunogen | IRGM antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of the human IRGM. The immunogen is located within amino acids 30 - 80 of IRGM. |
| Other Names | Ifi1|Iigp3|Iipg3|Irgm|LRG-47|LPS-stimulated RAW 264.7 macrophage protein 47|immunity-related GTPase family M protein 1|immunity-related GTPase family|M|interferon inducible protein 1|interferon-inducible GTPase 3|interferon-inducible protein 1|immunity-related GTPase family M member 1|Irgm1|Immunity-Related GTPase Family, M|immunity-related GTPase family M protein|immunity-related GTPase M|LRG47|LPS-stimulated RAW 264.7 macrophage protein 47 homolog|LRG-47-like protein|M1|immunity related GTPase M|LOC481473 |
| Gene, Accession # | Gene ID: 15944, 303090, 345611 |
| Catalog # | ABIN6990882 |
| Price | $519 |
| Order / More Info | IRGM Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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