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Antigenic Specificity | THRA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 100 µg |
Concentration | 0.89 mg/mL |
Applications | ELISA, Western Blotting |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Thyroid hormone receptor alpha is a nuclear hormone receptor with high affinity for the hormone triiodo-thyronine. THRA is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having a certain extent of redundancy, may mediate different functions of thyroid hormone. THRA interacts with NCOA3 and NCOA6 co-activators, leading to a strong increase in transcription of target genes. THRA is localized within the nucleus and has been found to exist as 4 isoforms originating from alternative splicing variants. Isoform 1 has a distinct C-terminus compared to isoform 2.Target Information: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. |
Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminus of human THRA isoform 1 protein. Immunogen Type: Peptide |
Other Names | AR7|CHNG6|EAR7|ERB-T-1|ERBA|ERBA1|NR1A1|THRA1|THRA2|c-ERBA-1|EAR-7|ERBA-related 7|V-erbA-related protein 7|c-erbA-alpha|nuclear receptor subfamily 1 group A member 1|thyroid hormone receptor alpha|thyroid hormone receptor|alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog|avian)|thyroid normone nuclear receptor alpha variant 1|triiodothyronine receptor|thyroid hormone receptor, alpha|THRA|thyroid hormone receptor alpha 2|TRalpha|c-erba|nr1a1-A|thra-A|TRalphaA|nuclear receptor subfamily 1 group A member 1-A|thyroid hormone receptor alpha-A|alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog)|xenTR-alpha1|thyroid hormone receptor, alpha L homeolog|thra.L|TRa1|thral|tra|wu:fb59g07|TRalpha-1|thyroid hormone receptor alpha 1|thyroid hormone receptor alpha-1|zTRalpha-A|thyroid hormone receptor alpha a|thraa|Thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1)|avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1|c-erb-A thyroid hormone receptor|c-erbA-alpha2|6430529J03Rik|AW259572|Rvr|T3Ra|T3Ralpha|TR alpha 1|TR alpha 2|c-erbAalpha|c-erb-A protein|C-ERBA ALPHA1|thyroid hormone receptor alpha1|tr-alpha|thyroid hormone receptor alpha2|fTHRalphaA|THR-alpha-A|LOC109641414 |
Gene, Accession # | Gene ID: 9572 |
Catalog # | ABIN233838 |
Price | $537 |
Order / More Info | THRA Antibody from ANTIBODIES-ONLINE GmbH |
Product Specific References | n/a |