SNCA Antibody from ANTIBODIES-ONLINE GmbH
Search, find, compare suppliers for anti-SNCA antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | SNCA |
| Clone | RB07369 |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified |
| Size | 80 µL |
| Concentration | n/a |
| Applications | Immunohistochemistry (Paraffin-embedded Sections), Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues. Additional splicing may be present but the full-length nature of these variants has not been determined. This variant (NACP112) lacks an alternate in-frame segment, compared to variant NACP140, resulting in a shorter protein (isoform NACP112) that has a distinct C-terminus, compared to isoform NACP140. This antibody recognizes both NACP112 and NCAP140. Target Information: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]. |
| Immunogen | This SNCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 amino acids from the C-terminal region of human SNCA. |
| Other Names | NACP|PARK1|PARK4|PD1|alpha-synuclein|non A-beta component of AD amyloid|synuclein alpha-140|synuclein alpha|SNCA|Synuclein, alpha|alphaSYN|alpha SYN|non-A beta component of AD amyloid|non-A4 component of amyloid|MGC64356|synuclein|alpha|synuclein alpha L homeolog|snca.L|LOC619283|alpha synuclein|alpha-synuclein isoform NACP140|alpha-synuclein-like|alpha (non A4 component of amyloid precursor) |
| Gene, Accession # | Gene ID: 6622 |
| Catalog # | ABIN2840770 |
| Price | $181 |
| Order / More Info | SNCA Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
P: +49 (0)241 95 163 153
F: +49 (0)241 95 163 155
info@antibodies-online.com
Orders: orders@antibodies-online.com
Technical Support: support@antibodies-online.com
https://www.antibodies-online.com
Profile of ANTIBODIES-ONLINE GmbH
Return to Antibodies