CD45 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD45 |
| Clone | OX-30 |
| Host Species | Mouse |
| Reactive Species | rat |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 500 µg |
| Concentration | 1.0 mg/ml . |
| Applications | Flow Cytometry, Immunohistochemistry (Frozen Sections) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | anti-rat CD45 (Leukocyte Common Antigen) monoclonal antibody recognizes a monomorphic determinant of the rat leukocyte common antigen.(1) The antigen recognized is a heavily glycosylated membrane glycoprotein of molecular weight 170,000 kDa on thymocytes but molecular weight 170,000-220,000 kDa on other leukocytes. The leukocyte common antigen (L-CA) is a major glycoprotein of haematopoietic cells but is not found on other tissues or erythroid cells. It is present on greater than 95% of thymocytes, bone marrow cells and thoracic duct lymphocytes. This molecule carries much of the carbohydrate of thymocytes and shows interesting heterogeneity amongst T lymphocytes and B lymphocytes. (2,3) This antibody is suitable for use in flow cytometry and immunohistochemistry with frozen sections. This clone has been reported to be unsuitable for use with paraffin sections. Target Information: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]. |
| Immunogen | lymph node glycoproteins and cells . Fusion Partner: NSO/U . Donor: BALB/c spleen |
| Other Names | B220|CD45|CD45R|GP180|L-CA|LCA|LY5|T200|CD45 antigen|T200 glycoprotein|T200 leukocyte common antigen|protein tyrosine phosphatase|receptor type|c polypeptide|receptor-type tyrosine-protein phosphatase C|protein tyrosine phosphatase, receptor type C|PTPRC|Protein tyrosine Phosphatase, Receptor Type, C|RT7|receptor-type|leucocyte common antigen|leukocyte common antigen A|leukocyte common antigen B|leukocyte common antigen|C|si:dkeyp-47c5.1|LOC100074271|receptor-type tyrosine-protein phosphatase C-like|Ly-5|Lyt-4|loc|lymphocyte antigen 5|lymphocyte common antigen|membrane tyrosine phosphatase|LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C-like|LOC109046999 |
| Gene, Accession # | Gene ID: 24699 |
| Catalog # | ABIN133156 |
| Price | $509 |
| Order / More Info | CD45 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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