KAPPA, CD19 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | KAPPA, CD19 |
| Clone | Nam75-5F3-A3-B1 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 50 tests |
| Concentration | n/a |
| Applications | Flow Cytometry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti- Kappa Light Chains reacts with free kappa chains as well as kappa chains in intact immunoglobulin molecules. The specificity has been ascertained as described below. Flow cytometry: When Anti- Kappa Light Chains is applied as described in the staining procedure in combination with Anti- CD19/ RPE, on lysed human whole blood, a specific staining of a part of the CD19- positive B lymphocytes is seen corresponding to the expected range of kappa light chain expression. Clinical applications: Flow cytometric analysis of single cell suspensions from formalin- fixed, paraffin- embedded tissue samples demonstrated that Anti- Kappa Light Chains labels reactive hyperplastic lymph nodes (10/ 10 cases). non- Hodgkin-s lymphomas, the antibody labeled 4/ 10 cases. The remaining cases were positive for lambda light chains (5/ 10 cases) or showed no expression of light chains (1/ 10 cases). Flow cytometric analysis of peripheral blood lymphocytes demonstrated that Anti- Kappa Light Chains labels a proportion of B- cell chronic lymphocytic leukaemias. Thus, in one study of 121 cases , 37 were positive for kappa. another study of 165 cases (3), 97 were positive for kappa. Anti- CD19, labels human B cells in peripheral blood, bone marrow and other tissues. Additionally, B- cell lymphoproliferative disorders gave positive reactions with the antibody, i. e. acute lymphoblastic leukaemia, chronic lymphocytic leukaemia, hairy cell leukaemia, lymphoblastic lymphoma (Burkitt type), centroblastic/ centrocytic lymphoma, and diffuse non- Hodgkin-s lymphoma. The antibody was shown to be unreactive with other cells in the human haema-topoietic system and did not react with non- haematopoietic cells, e. g. kidney, liver, breast or lung tissues. |
| Immunogen | n/a |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | ABIN1112413 |
| Price | $369 |
| Order / More Info | KAPPA, CD19 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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52072 Aachen GERMANY
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