CD28 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD28 |
| Clone | CD28-2 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | biotin conjugate |
| Size | 100 µg |
| Concentration | n/a |
| Applications | Flow Cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The CD28.2 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of receptors include CTLA -4 (CD152), PD-1 (CD279), ICOS and BTLA.The CD28.2 antibody may be used as a phenotypic marker for human CD28, expressed on all CD4 T cells and CD8 T cells, and is widely used as a reagent for activation of the CD28 receptor in vitro and in vivo (use format suitable for functional assays). This antibody is also reported to be cross-reactive with several non-human species, including Baboon, Chimpanzee, Cynomolgus, and Rhesus. Target Information: The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]. |
| Immunogen | n/a |
| Other Names | Tp44|CD28 antigen|T-cell-specific surface glycoprotein CD28|CD28 molecule|CD28|CD28RNA|CD28 antigen (Tp44)|CHT28|T-cell-specific surface glycoprotein CD28 homolog|T-cell costimulatory molecule CD28|cell surface protein|costimulatory molecule B7 receptor CD28|antigen CD28|T-cell specific surface glycoprotein CD28|CD28 precursor protein|T-cell-specific surface glycoprotein CD28-like protein|CD28 molecule L homeolog|cd28.L |
| Gene, Accession # | Gene ID: 2566 |
| Catalog # | ABIN7278098 |
| Price | $206 |
| Order / More Info | CD28 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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