Tubulin Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | Tubulin |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | dog, human, mouse |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | lot specific |
| Applications | Immunocytochemistry, Immunoprecipitation, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: Microtubules are key cytoskeletal elements that are found in all eukaryotic cells. Microtubules fulfil a large range of different functions, which are thought to be controlled by the 'tubulin code' - mechanism to generate distinct microtubule identities. One mechanism to label specific microtubules are tubulin posttranslational modifications (PTMs), of which a large variety exists. One of these modifications is glycylation, which is generated by the addition of secondary (branched) glycine chains to the main (primary) peptide chain of the protein. The length of these branch chains can vary from one to more than 20 glycine residues. Glycylation is catalysed by the enzymes TTLL3, TTLL8 and TTLL10 from the tubulin tyrosine ligase-like (TTLL) family. Especially TTLL3 and TTLL8 are essential for the initiation of the glycylation because the generate the nascent glycine chain. The Gly-pep1 antibody was raised against a peptide mimicking beta2-tubulin (TUBB2A) with a single glycine branch on E437. The antibody specifically detects glycylated tubulin, and also other yet unknown glycylation substrates in cells as well as in tissues. As glycyation of microtubules is particularly found in cilia and flagella, Gly-pep1 labels motile cilia as well as primary cilia (Gadadhar et al. 2017) |
| Immunogen | Synthetic peptide corresponding to D431EQGEFE(G-COOH*)EEEG441-NH2 of human Tubulin beta-2A chain (*secondary glycine branched from gamma-carboxyl group of glutamate as isopeptide bond). |
| Other Names | 4t|B4t|BETA 98B|CG4869|DTB1|Dmbeta4|DmelCG4869|T|Tub|beta-Tub|beta-Tub97EF|beta4|beta4t|beta97F|betaTub4|betaTub98BC|betaTub98C|Beta4-tubulin|CG4869-PB|CG4869-PC|beta tubulin|beta-Tubulin|beta4 tubulin|betaTub97EF-PB|betaTub97EF-PC|betatubulin|tubulin|beta-Tubulin at 97EF|betaTub97EF |
| Gene, Accession # | Gene ID: 43359 |
| Catalog # | ABIN6253484 |
| Price | $563 |
| Order / More Info | Tubulin Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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