CD25 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD25 |
| Clone | PC61-5 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG1 lambda |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 µg |
| Concentration | n/a |
| Applications | Flow Cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The PC61.5 antibody is specific for mouse CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL- 2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Expression of CD25 varies during developmental stages of T and B cells, is induced on activated mature T and B cells, and is present on subsets of dendritic cells. CD25 signaling as part of the IL-2 receptor complex triggers T cell activation and proliferation, as well as modulating the differentiation and function of Th17 cells, T regulatory (Treg) cells, and dendritic cells. The PC61.5 antibody is used as a marker for T cells, B cells and dendritic cell subsets. Expression of CD25, CD4 and the transcription factor Foxp3 is regarded as a phenotypic signature for Treg cells. As such, this antibody is widely used for depletion of Treg cells in vivo, as well as to distinguish Treg cells from naive or conventional T cells which are CD25-. Target Information: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]. |
| Immunogen | n/a |
| Other Names | CD25|IDDM10|IL2R|TCGFR|IL-2 receptor subunit alpha|IL-2-RA|IL-2R subunit alpha|IL2-RA|TAC antigen|interleukin-2 receptor subunit alpha|p55|interleukin 2 receptor subunit alpha|IL2RA|Interleukin 2 Receptor, alpha|IL2RAC|IL-2 receptor alpha subunit|interleukin 2 receptor|alpha chain|interleukin-2 receptor alpha chain|IL-2 alpha receptor|IL2 receptor alpha|interleukin-2 alpha receptor|IL-2RA|interleukin 2 receptor alpha chain|interleukin-2 receptor alpha subunit|IL-2 Receptor alpha chain|alpha|interleukin-2 receptor subunit alpha-like|LOC100222957|Ly-43|IL-2R alpha chain|p55 chain|interleukin 2 receptor, alpha chain|IL-2R alpha|cytokine receptor|CD25 antigen |
| Gene, Accession # | Gene ID: 16184 |
| Catalog # | ABIN7277979 |
| Price | $215 |
| Order / More Info | CD25 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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