TCR beta Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | TCR beta |
| Clone | H57-597 |
| Host Species | Armenian Hamster |
| Reactive Species | mouse |
| Isotype | IgG |
| Format | fluorescein (FITC) conjugate |
| Size | 25 µg |
| Concentration | n/a |
| Applications | Flow Cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1 thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma and delta protein chains, known as the gamma-delta TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can re- sult in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the gamma-delta TCR. Target Information: T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment, a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes several trypsinogen genes. [provided by RefSeq, Jul 2008] |
| Immunogen | n/a |
| Other Names | TCRbeta|Tib|T-cell receptor beta chain|T cell receptor beta chain|Tcrb|T Cell Receptor (TCR) beta|TCR beta|CDR3|TCR|TCRBV20S2|TCRBV2O|TCRBV2S2O|TRB|T cell receptor beta variable 20OR9-2 pseudogene|T-cell receptor beta chain variable region|T-cell receptor|beta variable region 2|orphon|TRBV20OR9-2|T cell receptor beta variable 20/OR9-2 (non-functional)|TRBV20OR9-2 |
| Gene, Accession # | Gene ID: 6962, 21577 |
| Catalog # | ABIN6961422 |
| Price | $60 |
| Order / More Info | TCR beta Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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52072 Aachen GERMANY
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