PROC Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | PROC |
| Clone | polyclonal |
| Host Species | Goat |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 1 mL |
| Concentration | n/a |
| Applications | ELISA, Immunodiffusion, Immunoelectrophoresis, Nephelometry, Radial Immunodiffusion |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Goat anti-PROC polyclonal antibody, unconjugated |
| Immunogen | Protein C is a glycoprotein (MW 60,000) which is synthesized in the liver. It acts as a trypsin like serine protease but functions in a manner different from that of antithrombin III. Activated protein C (pCa) results from proteolytic cleavage of protein C by thrombin and with protein S (pS) as a cofactor it cleaves factors Va and VIIIa, producing anti-coagulation by decreasing the conversion of prothrombin to thrombin. It also stimulates the fibrinolytic system by inactivating the inhibitor of tissue plasminogen activator (TPA), an enzyme that converts plasminogen into plasmin which cleaves fibrin into fibrin split products. Protein C is consumed during coagulation in vivo. Very little protein C is activated during coagulation in vitro, because this requires the presence of thrombomodulin, a thrombin receptor on endothelial cells. The coagulant activity of protein C is species specific and pCa is specifically regulated by protein C inhibitor (pCI) in the presence of heparin. Normal human plasma contains an average of 0.3 mg/ml. The normal newborn has a protein C level that is 30 to 40% of the normal adult level. Numerous cases with a genetical protein C deficiency associated with thrombotic disease have been reported, frequently with an extensive family history of thrombosis. Patients with a partial protein C deficiency are subject to severe, recurrent deep venous thrombosis and pulmonary embolism. The plasma protein C level should be determined before beginning anticoagulation therapy. Total protein C deficiency in the newborn leads to purpurea fulminans, the diagnosis may be confirmed by determining the protein C levels in both heterozygous parents. Acquired protein C deficiency may result of treatment with oral anticoagulants and of various liver diseases. Plasma protein C levels may also decrease after intravascular coagulation. Freund's complete adjuvant is used in the first step of the immunization procedure. |
| Other Names | anticoagulant protein C|autoprothrombin IIA|blood coagulation factor XIV|vitamin K-dependent protein C|protein C, inactivator of coagulation factors Va and VIIIa|PROC|si:ch1073-188c16.3|zgc:63987|procl|protein C|protein C (inactivator of coagulation factors Va and VIIIa), a|proca|protein C (precursor of vitamin K-dependent serine protease)|APC|protein C (inactivator of coagulation factors Va and VIIIa)|catalytic region|PC|PROC1|THPH3|THPH4|MGC64425|protein C, inactivator of coagulation factors Va and VIIIa S homeolog|proc.S|vitamin K-dependent protein C-like|CpipJ_CPIJ000393|CpipJ_CPIJ002754|CpipJ_CPIJ003717|CpipJ_CPIJ003718|CpipJ_CPIJ014440|CpipJ_CPIJ018032|CpipJ_CPIJ018737|proactivator polypeptide|prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)|prosaposin|PSAP|inactivator of coagulation factors Va|VIII|PA|proline rich protein HaeIII subfamily 1|PRH1 |
| Gene, Accession # | Gene ID: 5554 |
| Catalog # | ABIN458051 |
| Price | $492 |
| Order / More Info | PROC Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
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