ROCK2 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | ROCK2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Progression of tumors to invasive and metastatic forms requires that tumor cells undergo dramatic morphological changes, a process regulated by Rho GTPases. Increased levels of RhoA or RhoC, as well as the Rho effector proteins ROCK-1 or ROCK-2, were observed in various human carcinomas. In vivo studies have also shown that ROCK inhibition reduced the invasiveness of several tumor cell lines. It is suggested that Rho and ROCK signaling contribute to the morphological changes and metastatic behavior of some tumor cells. Thus, elevated Rho and ROCK expression is associated with tumorigenesis, particularly during the progression to invasive and metastatic phenotypes. Phosphorylation of certain residues in ROCK-2 may be critical for its kinase activity.Target Information: The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]. |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to residues surrounding Y256 of human ROCK-2. |
| Other Names | ROCK-II|p164 ROCK-2|rho-associated protein kinase 2|rho-associated|coiled-coil-containing protein kinase II|Rho associated coiled-coil containing protein kinase 2|ROCK2|rho-Associated, Coiled-Coil Containing Protein Kinase 2|coiled-coil-containing protein kinase 2|rok2|coiled-coil containing protein kinase 2|rho-associated, coiled-coil containing protein kinase 2a|rock2a|rho-associated protein kinase 2-like|ROK|ROKalpha|Rho-associated coiled-coil forming kinase 2|RhoA - binding serine hreosine kinase alpha (ROK - alpha)|p150 ROK-alpha|rhoA-binding kinase 2|Rho-associated coiled-coil containing protein kinase 2|B230113H15Rik|Rho-kinase|Rock2m|mKIAA0619|Rho-associated coiled-coil forming kinage 2|rocka-a|xROK|Rho-associated kinase alpha|Rho-associated, coiled-coil containing protein kinase 2 L homeolog|rock2.L|Rho-kinase alpha |
| Gene, Accession # | Gene ID: 9475 |
| Catalog # | ABIN233829 |
| Price | $537 |
| Order / More Info | ROCK2 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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