Integrin Alpha2b Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | Integrin Alpha2b |
| Clone | HIP8 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 100 tests |
| Concentration | n/a |
| Applications | Flow Cytometry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This clone has been clustered to CD41 in the fourth international Workshop on Human White Cell differentiation Antigens. The antibody recognises the intact platelet gpIIb/IIIa complex, it does not bind to dissociated gpIIb or gpIIIa only to gpIIb in the intact complex. This is found on platelets, megakaryocytes and monocytes. Acute megakaryoblastic l leukaemia cells are positive for the gpIIb/IIIa antigen whereas common myeloid leukaemias are negative. CD41 is expressed on platelets and megakaryocytes. CD41 is the integrin aIIb subunit that is expressed as a heterodimer non-covalently associated with the integrin b3 subunit CD61. The association between CD41 and CD61 is calcium dependent. Target Information: ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]. |
| Immunogen | n/a |
| Other Names | BDPLT16|BDPLT2|CD41|CD41B|GP2B|GPIIb|GT|GTA|HPA3|GPalpha IIb|integrin alpha-IIb|platelet fibrinogen receptor|alpha subunit|platelet membrane glycoprotein IIb|platelet-specific antigen BAK|integrin subunit alpha 2b|ITGA2B|Integrin Alpha2b|AI172977|alphaIIb|GP IIb|alpha IIb|platelet glycoprotein IIb of IIbII Ia complex|integrin alpha 2b|LOW QUALITY PROTEIN: integrin alpha-IIb|integrin alpha 2b (Cd41b)|integrin|alpha 2B|si:dkey-27b3.6|glycoprotein IIb|alpha 2b (platelet glycoprotein IIb of IIbIIIa complex|antigen CD41B)|integrin, alpha 2b |
| Gene, Accession # | Gene ID: 3674 |
| Catalog # | ABIN1112135 |
| Price | $316 |
| Order / More Info | Integrin Alpha2b Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
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