GFAP Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | GFAP |
| Clone | polyclonal |
| Host Species | Chicken |
| Reactive Species | cow |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µL |
| Concentration | n/a |
| Applications | Immunofluorescence, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques (1). It was subsequently found to be a member of the 10nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers (2). Anti-GFAP Left: Western blot of rat cortex lysate showing specific immunolabeling of the ~ 50k GFAP protein. Right: Mixed cultures of neurons and glia stained with chicken anti-GFAP (red), and DNA (blue). Astrocytes stain strongly and specifically in a clearly filamentous fashion with this antibody. Target Information: This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]. |
| Immunogen | Recombinant and purified bovine GFAP |
| Other Names | glial fibrillary acidic protein|GFAP|AI836096|intermediate filament protein|glial fibrillary acidic protein alpha|intermediate filament|cb345|etID36982.3|gfapl|wu:fb34h11|wu:fk42c12|xx:af506734|zgc:110485|zrf-1 antigen|LOC100136168 |
| Gene, Accession # | Gene ID: 281189 |
| Catalog # | ABIN361379 |
| Price | $481 |
| Order / More Info | GFAP Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
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