NK-1.1/CD161c Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | NK-1.1/CD161c |
| Clone | PK136 |
| Host Species | Mouse |
| Reactive Species | mouse |
| Isotype | IgG2a kappa |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | n/a |
| Applications | Flow Cytometry, Functional Studies, Immunofluorescence, Immunohistochemistry (Frozen Sections), Immunoprecipitation |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1 /CD117 (c-Kit) cells reported to be immunosuppressive for CD8 T cells in a mechanism involving PD-1 and PD-L1. (Ehlers et al. 2012. Endocrinology. 10: 1247.)The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524). Target Information: Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2 ) mobilization and interferon-gamma production. |
| Immunogen | n/a |
| Other Names | AI462337|CD161|Ly-59|Ly55c|Ly59|NK-RP1|NK1.1|NKR-P1.9|NKRP1|NKRP140|Nk-1|Nk-1.2|Nk1|Nk1.2|Nkrp1c|ly-55c|CD161 antigen-like family member C|NKR-P1 40|killer cell lectin-like receptor subfamily A member 1C|lymphocyte antigen 55 complex|locus C|lymphocyte antigen 55c|lymphocyte antigen 59|natural killer cell receptor protein NKR-P1C|natural killer cell receptor-P1|natural killer cell surface protein P1-40|natural killer cell-associated antigen 1|killer cell lectin-like receptor subfamily B member 1C|Klrb1c|NK-1.1|NK-1.1/CD161c|Klrb1f|NKR-P1F|NKR-P1B protein|Natural killer cell surface protein NKR-P1F|killer cell lectin-like receptor subfamily B member 1B|killer cell lectin-like receptor subfamily B member 1F |
| Gene, Accession # | Gene ID: 17059 |
| Catalog # | ABIN6961464 |
| Price | $145 |
| Order / More Info | NK-1.1/CD161c Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
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