PSMB11 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | PSMB11 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µL |
| Concentration | n/a |
| Applications | Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PSMB11 belongs to the peptidase T1B family. It is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basicpH. PSMB11 has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. It plays a pivotal role in development of CD8-positive T cells. The antibody is specific to PSMB11. Target Information: Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6, MIM 600307), beta-2 (PSMB7, MIM 604030), and beta-5 (PSMB5, MIM 600306). Three additional subunits, beta-1i (PSMB9, MIM 177045), beta-2i (PSMB10, MIM 176847), and beta-5i (PSMB8, MIM 177046), are induced by gamma-interferon (IFNG, MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 |
| Immunogen | Recombinant protein corresponding to Mouse PSMB11 |
| Other Names | 5830406J20Rik|beta5t|proteasome beta 11 subunit|proteasome subunit beta type-11|proteasome subunit beta-5t|proteasome subunit beta5t|proteasome (prosome, macropain) subunit, beta type, 11|Psmb11|proteasome subunit beta 5T|proteasome subunit beta 11|RGD1308773|proteasome (prosome|macropain) subunit|beta type|11|beta1t|macropain|prosome|zgc:92422|12|proteasome subunit beta 12|psmb12 |
| Gene, Accession # | Gene ID: 73902, 290206 |
| Catalog # | ABIN7075228 |
| Price | $286 |
| Order / More Info | PSMB11 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
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