MYH11 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | MYH11 |
| Clone | MYH11-923 |
| Host Species | Mouse |
| Reactive Species | human, rat |
| Isotype | IgG1 kappa |
| Format | unconjugated |
| Size | 20 µg |
| Concentration | 200 µg/mL |
| Applications | Flow Cytometry, Immunofluorescence, Immunohistochemistry, Staining Methods |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Smooth muscle myosin heavy chain (SM-MHC) is a cytoplasmic structural protein, which is a major component of the contractile apparatus in smooth muscle cells. Expression of smooth muscle myosin is developmentally regulated, appearing early in smooth muscle development, and is specific for smooth muscle development. Two isoforms of smooth muscle myosin heavy chain have been identified, designated MHC-1 and MHC-2. The antibody may be useful for the study of breast tumors as the presence of an intact layer of myoepithelial cells is an important feature, which may distinguish benign breast lesions and carcinoma in situ from invasive tumors. Target Information: The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. |
| Immunogen | Recombinant full-length human MYH11 protein |
| Other Names | AV071570|SM1|SM2|smMHC|myosin heavy chain 11|smooth muscle|myosin heavy chain|smooth muscle isoform|myosin-11|myosin, heavy polypeptide 11, smooth muscle|Myh11|Myosin Heavy Chain 11, Smooth Muscle|myosin heavy chain 21|myosin|heavy polypeptide 11|smooth muscle myosin heavy chain|AAT4|FAA4|SMHC|MHC|gizzard smooth muscle|myosin, heavy chain 11, smooth muscle|myosin heavy chain SMA|meltdown|mlt|smooth muscle a|myosin, heavy chain 11a, smooth muscle|myh11a|LOW QUALITY PROTEIN: myosin-11|heavy chain 11 |
| Gene, Accession # | Gene ID: 4629, 24582 |
| Catalog # | ABIN6934975 |
| Price | $274 |
| Order / More Info | MYH11 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
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