CD31 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD31 |
| Clone | ER-MP12 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | n/a |
| Applications | Flow Cytometry, Immunoassay, Immunohistochemistry (Paraffin-embedded Sections), Immunoprecipitation |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The monoclonal antibody ER-MP12 recognizes mouse platelet endothelial cell adhesion molecule-1 (PECAM-1,CD31). PECAM-1 is a 130 kDa glycoprotein involved in cell adhesion and a signalling receptor that is expressed on hematopoietic and endothelial cells. It is a member of the immunoglobulin (Ig)-superfamily of cell adhesion molecules. The type I transmembrane protein is composed of an extracellular region of six Ig-like homology domains, a 19-residue transmembrane domain, and a 118 residue cytoplasmic tail and is differentially glycosylated involving N-linked and O- linked glycosylation sites. The signalling of PECAM-1 is based on 2 immuno receptor tyrosine inhibitory motifs (ITIMs) in its cytoplasmic domain. These ITIM domains can serve as docking sites for signalling molecules such as protein tyrosine phosphatases, and ligation of PECAM-1 can induce phosphorylation of tyrosine- and serine/threonine-residues of these intracellular regions eventually leading to activation of signalling pathways. The biological characteristics of PECAM-1 in these pathways and cellular adhesion have been mapped to specific regions of the PECAM-1 Molecule. PECAM-1 is abundantly expressed on endothelial cells, where it is a major constituent of the endothelial cell intercellular junction in confluent vascular beds, making it a commonly used endothelial marker. Furthermore, it is expressed on most cells of the hematopoietic lineage including platelets, monocytes, neutrophils, and lymphocyte subsets. Besides adhesive properties PECAM-1 is an efficient signalling molecule. The protein is involved in vascular biology including angiogenesis, platelet function, and thrombosis, mechanosensing of endothelial cells, and regulation of multiple stages of leukocyte migration through venular walls. PECAM-1 is also a regulator of inflammatory responses. It has been shown to serve a variety of pro-inflammatory and anti-inflammatory functions. Pro-inflammatory functions of PECAM-1 include the facilitation of leukocyte transendothelial migration and the transduction of mechanical signals in endothelial cells originating from fluid shear stress. Anti- inflammatory functions include the dampening of leukocyte activation, suppression of pro- inflammatory cytokine production, and the maintenance of vascular barrier integrity. Monoclonal antibody ER-MP12 reacts also with the major population of colony forming unit macrophage (CFU-M) precursor cells, with a subpopulation of pre CFU-M and monoblasts, and with precursor cells of granulocytes. The antibody can also be used, in combination with the monoclonal antibody ER-MP20, for identification of different stages of myeloid progenitor cell development. Aliases Platelet endothelial cell adhesion molecule-1, CD31, EndoCam 1 Immunogen Mouse macrophage precursor hybrid cells. W1C3 Target Information: The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]. |
| Immunogen | n/a |
| Other Names | CD31|CD31EndoCAM|GPIIA'|PECA1|PECAM-1|endoCAM|CD31 antigen|platelet endothelial cell adhesion molecule|platelet and endothelial cell adhesion molecule 1|PECAM1|Platelet/endothelial Cell Adhesion Molecule|platelet/endothelial cell adhesion molecule 1|C85791|Pecam|PECAM-1CD31|plateletendothelial cell adhesion molecule (CD31 antigen)|type I transmembrane endothelial adhesion molecule|platelet endothelial cell adhesion molecule-1|platelet and endothelial cell adhesion molecule 1 L homeolog|plateletendothelial cell adhesion molecule 1 L homeolog|pecam1.L |
| Gene, Accession # | Gene ID: 18613 |
| Catalog # | ABIN2191833 |
| Price | $550 |
| Order / More Info | CD31 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
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