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Antigenic Specificity | CD45RC |
Clone | RP1-12 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 100 tests |
Concentration | n/a |
Applications | Flow Cytometry, Immunofluorescence |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody reacts with CD45RC on pre-B lymphocytes,B cells,CD8 T suppressor/cytotoxic cells,and a subset of CD4 T helper (Th)lymphocytes. It weakly reacts with thymocytes.4 CD45RC is a high-molecular-weight isoform of CD45 (Leukocyte Common Antigen),its level of expression distinguishes subpopulations of CD4 T cells with Th1-like and Th2-like effector functions. Levels of expression of CD45RC have also been reported to distinguish resting from activated T cells at various stages of maturation. CD45 is a member of the Protein Tyrosine Phosphatase (PTP)family:Its intracellular (COOH-terminal)region contains two PTP catalytic domains,and the extracellular region is highly variable due to alternative splicing of exons 4,5,and 6 (designated A,B,and C,respectively),plus differing levels of glycosylation. The CD45 isoforms detected in the rat are cell type-,maturation-,and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. Target Information: member of a family of heavily glycosylated leukocyte cell surface glycoproteins, displays extensive O-glycosylation [RGD, Feb 2006]. |
Immunogen | n/a |
Other Names | B220|CD45|CD45R|GP180|L-CA|LCA|LY5|T200|CD45 antigen|T200 glycoprotein|T200 leukocyte common antigen|protein tyrosine phosphatase|receptor type|c polypeptide|receptor-type tyrosine-protein phosphatase C|protein tyrosine phosphatase, receptor type C|PTPRC|CD45RC|RT7|receptor-type|leucocyte common antigen|leukocyte common antigen A|leukocyte common antigen B|protein tyrosine phosphatase, receptor type, C |
Gene, Accession # | Gene ID: 5788 |
Catalog # | ABIN1112167 |
Price | $704 |
Order / More Info | CD45RC Antibody from ANTIBODIES-ONLINE GmbH |
Product Specific References | n/a |