CD4 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD4 |
| Clone | W3-25 |
| Host Species | Mouse |
| Reactive Species | rat |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 250 µg |
| Concentration | n/a |
| Applications | Flow Cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | anti-rat T helper cell monoclonal antibody recognizes a determinant on the majority of thymocytes (90-95%), a subset of peripheral T cells and peritoneal macrophages. (1,2,3,10.) The antigen recognized by this antibody is a surface glycoprotein of Mr 48 000 - 52 000 and is the homologue of the human CD4 and the mouse L3/T4 antigen. ABIN133174labels the rat T helper subset, which mediates the helper activity for B and T cells, graft vs. host (GVH) reactivity and produces IL-2 in the mixed lymphocyte reaction (MLR). (2,4,6) Addition of ABIN133174to the MLR, inhibited proliferation and blocks the production of IL- 2. (4,5,6,9) T cells which mediate cytotoxicity and suppressor functions are not labelled. (Thus, cells labelled by this antibody are not labelled by MRC OX-8.) ABIN133174is invaluable for separating T cell subsets for functional studies and for labelling cells in tissue sections. It has been used in studying the role of T lymphocytes in graft rejections (7) and in studying the subsets of T cells in the rat which mediate graft vs. host disease. (8) This particular antibody is also one of three antibodies which labels T lymphocyte populations in the rat. These clones include W3/13 ABIN133174, which labels all T cells, as well as MRC OX-8 ABIN133174 and W3/25 ABIN133174 which label non-overlapping T cell subpopulations. These monoclonal antibodies used in concert are being employed extensively to investigate cellular aspects of the immune response in rats and prove to be useful as markers for functionally distinct subpopulations of lymphocytes. This clone is reported to work with frozen and paraffin sections (11) and functional testing (12). Target Information: This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]. |
| Immunogen | Rat thymocyte membrane . Fusion Partner: P3-NSI/1-Ag 4 . Donor: BALB/c spleen |
| Other Names | CD4mut|CD4 antigen (p55)|CD4 receptor|T-cell surface antigen T4Leu-3|T-cell surface glycoprotein CD4|CD4 molecule|CD4|W325|p55|CD4 antigen|W325 antigen|L3T4|Ly-4|T-cell differentiation antigen L3T4|T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4Leu-3) (T-cell differentiation antigen L3T4)|carcinoembryonic antigen-related cell adhesion molecule 5|LOC100125525|lymphocyte antigen CD4|cell surface glycoprotein CD4|cd1|cd11|cd12|cd19|cd2|cd23|cd5|cd6|cd9|ighv1s1|ighv1s3|ighv1s4|immunoglobulin heavy variable 1 subgroup 1|immunoglobulin heavy variable 1 subgroup 3|immunoglobulin heavy variable 1 subgroup 4|immunoglobulin heavy variable 1-1|ighv1-1 |
| Gene, Accession # | Gene ID: 24932 |
| Catalog # | ABIN133174 |
| Price | $288 |
| Order / More Info | CD4 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
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