ZAP70 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | ZAP70 |
| Clone | 2F3-2 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a kappa |
| Format | unconjugated |
| Size | 20 µg |
| Concentration | 200 µg/mL |
| Applications | Flow Cytometry, Immunofluorescence, Immunohistochemistry, Staining Methods |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene.In Western blotting of whole cell lysates of normal peripheral blood mononuclear cells, the antibody labels a band corresponding to ZAP70. In Western blotting of whole cell lysates of CD19-positive Purified leukemia cells from patients with Ig-unmutated and Ig-mutated CLL, the antibody labels a band corresponding to ZAP70 in the Ig-unmutated CLL samples, whereas no band is observed in the Ig-mutated CLL samples. In Western blotting of cell lysates of Jurkat cells (T-lymphoblastic cell line), the antibody labels a band of 70kDa protein. In Western blotting of cell lysates of A431 cells (carcinoma cell line), no band is observed. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis. Target Information: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. |
| Immunogen | Recombinant ZAP-70 protein including residues 1-254 and encompassing SH2 domains of human ZAP70 |
| Other Names | SRK|STCD|STD|TZK|ZAP-70|70 kDa zeta-associated protein|70 kDa zeta-chain associated protein|syk-related tyrosine kinase|tyrosine-protein kinase ZAP-70|zeta-chain associated protein kinase|70kD|zeta chain of T-cell receptor associated protein kinase 70|ZAP70|zeta-Chain (TCR) Associated Protein Kinase 70kDa|putative tyrosine-protein kinase zap-70|Smp_149470|70kDa|AI327364|mrtle|mur|zeta-chain (TCR) associated protein kinase|syk-related protein tyrosine kinase|zeta chain of T cell receptor associated protein kinase 70|MGC80670|zeta chain of T cell receptor associated protein kinase 70kDa L homeolog|zap70.L|MGC88962|zeta chain of T cell receptor associated protein kinase 70kDa|zeta-chain associated protein kinase 70kDa|LOC707555|LOC100342021|tyrosine-protein kinase ZAP-70-like|LOC100390922|LOC100542877|zgc:110383 |
| Gene, Accession # | Gene ID: 7535 |
| Catalog # | ABIN6936069 |
| Price | $274 |
| Order / More Info | ZAP70 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
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