tropomyosin, striated muscle Antibody from DEVELOPMENTAL STUDIES HYBRIDOMA BANK

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Antigenic Specificitytropomyosin, striated muscle
CloneCH1
Host SpeciesMouse
Reactive SpeciesAxolotl, broad species, chicken, fish, human, mouse, rat, Xenopus
IsotypeIgG1
FormatHYBRIDOMA
Size1 vial cells
Concentrationn/a
ApplicationsELISA,FFPE,Function Blocking,Immunofluorescence,Immunoprecipitation,Western Blot
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DescriptionEpitope: CH1 has been reported to bind to the peptide region encoded by exon 9a of TPM genes [PMID: 24958154]; this exon is well conserved in all vertebrates. But, the binding of CH1 has also been described to be limited to alpha9a [PMID: 22069507]. CH1 reacts strongly with striated muscle forms of tropomyosin, including cardiac alpha-tropomyosin and skeletal alpha- and beta-tropomyosins, but not with tropomyosin isoforms from gizzard (smooth muscle) or chicken embryo fibroblasts. CH1 interferes with the binding of tropomyosin to actin. CH1 recognizes sarcomeric Tm soforms alpha-fast, beta, and alpha-slow with poor affinity for alpha-slow. Antibody Registry ID: AB_2205770
ImmunogenPurified chicken cardiac muscle tropomyosin, Full length protein
Other Namesn/a
Gene, Accession #TPM1, Gene ID: 396366, UniProt: P04268
Catalog #CH1
Priceplease inquire
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Product Specific ReferencesPubMed: 3899907
DEVELOPMENTAL STUDIES HYBRIDOMA BANK
DEVELOPMENTAL STUDIES HYBRIDOMA BANK
DEVELOPMENTAL STUDIES HYBRIDOMA BANK
Dr. David Soll
University of Iowa Dept. Biology
Iowa City IA 52242
P: 319-335-3826
F: 319-335-2077

dshb@uiowa.edu

http://dshb.biology.uiowa.edu
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