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Antigenic Specificity | tropomyosin, striated muscle |
Clone | CH1 |
Host Species | Mouse |
Reactive Species | Axolotl, broad species, chicken, fish, human, mouse, rat, Xenopus |
Isotype | IgG1 |
Format | supernatant |
Size | 1 ml |
Concentration | n/a |
Applications | ELISA,FFPE,Function Blocking,Immunofluorescence,Immunoprecipitation,Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Epitope: CH1 has been reported to bind to the peptide region encoded by exon 9a of TPM genes [PMID: 24958154]; this exon is well conserved in all vertebrates. But, the binding of CH1 has also been described to be limited to alpha9a [PMID: 22069507]. CH1 reacts strongly with striated muscle forms of tropomyosin, including cardiac alpha-tropomyosin and skeletal alpha- and beta-tropomyosins, but not with tropomyosin isoforms from gizzard (smooth muscle) or chicken embryo fibroblasts. CH1 interferes with the binding of tropomyosin to actin. CH1 recognizes sarcomeric Tm soforms alpha-fast, beta, and alpha-slow with poor affinity for alpha-slow. Antibody Registry ID: AB_2205770 |
Immunogen | Purified chicken cardiac muscle tropomyosin, Full length protein |
Other Names | n/a |
Gene, Accession # | TPM1, Gene ID: 396366, UniProt: P04268 |
Catalog # | CH1 |
Price | please inquire |
Order / More Info | tropomyosin, striated muscle Antibody from DEVELOPMENTAL STUDIES HYBRIDOMA BANK |
Product Specific References | PubMed: 3899907 |