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Product Name | Sildenafil |
Description | A PDE5 inhibitor (IC50s = 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively); selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 µM, respectively); reverses glucose-induced decreases in ANG1 expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro; increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy; increases ICP/MAP ratio in castrated rats at 20 mg/kg per day; reduces cardiac arrest and resuscitation-induced increases in angiotensin II ACE, ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury |
Size | 50 mg |
Concentration | n/a |
Applications | n/a |
Other Names | PDE-5 1 3 ANG-1 ACE-2 |
Gene, Accession, CAS # | CAS: 139755-83-2 |
Catalog # | 10008671-50 |
Price | $115.00 |
Order / More Info | Sildenafil from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |