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Product Name | NCGC00244536 |
Description | A KDM4B/JMJD2B inhibitor (IC50 = ~10 nM); selective for KDM4B/JMJD2B over KDM5A/JARID1 and LSD1 but does inhibit KDM4A/JMJD2A, KDM4C/JMJD2C, and KDM4D/JMJD2D at 10 µM; inhibits the growth of various prostate cancer cells (IC50s = <1 µM for all); reduces androgen receptor levels and H3K9 trimethylation in isolated human solid prostate tumors; reduces tumor volume in a PC3 mouse xenograft model at 20 mg/kg |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | NCGC 00244536 KDM 4A 4B 4C 4D 5A JMJD 2A 2B 2C 2D JARID 1 LSD PC 3 DU 145 C42 H3 K9 |
Gene, Accession, CAS # | CAS: 2003260-55-5 |
Catalog # | 18478-1 |
Price | $49.00 |
Order / More Info | NCGC00244536 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |